Clearly one of the Basilca's focal points is the Main Altar. The altar features a nine-foot-tall, 1,600-pound statue of Our Lady of Victory which was sculpted in Italy and personally blessed by Pope Pius XI. In gratitude, Father Baker reserved a space for the painting of His Holiness to the left side of the altar.

Flanking the altar are four swirled marble columns of rare red marble. Reminiscent of St. Peter's Basilica in Rome, the columns' appearance in the shrine smacks of Divine intervention. The story goes that a group of Buffalo-born soldiers stumbled upon the unique red marble while in Spain during World War I. Upon seeing it, the GIs thought immediately of the wonderful church being built back home by Father Baker, and they ran to the Spanish farmer who owned the property the marble was on. After receiving a crash course on the "Padre of the Poor" and his "City of Charity", the farmer agreed to donate the "useless rock" on his property. Arragements were made, and, shortly after, the marble made it's way to Lackawanna.

The Main Altar stands under a bright blue dome depicting the Holy Spirit in brilliant hues. On the ceiling over the altar, an elongated panel represents "Queen of All Saints" -- among the saints are Mary Magdelene, Anthony, Elizabeth, Anne, and Theresa.